Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.

GPTomics506

Bioinformática

Bio Clinical Databases Tumor Mutational Burden

Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds. Use when assessing immunotherapy eligibility or characterizing tumor immunogenicity.

GPTomics506

Bioinformática

Bio Longitudinal Monitoring

Tracks ctDNA dynamics over time for treatment response monitoring using serial liquid biopsy samples. Analyzes tumor fraction trends, mutation clearance kinetics, and defines molecular response criteria. Use when monitoring patients during therapy or detecting molecular relapse before clinical progression.

GPTomics506

Bioinformática

Bio Liquid Biopsy Pipeline

Cell-free DNA analysis pipeline from plasma sequencing to tumor monitoring. Preprocesses cfDNA reads, analyzes fragment patterns, estimates tumor fraction from sWGS, and optionally detects mutations from targeted panels. Use when analyzing liquid biopsy samples for cancer detection or monitoring.

GPTomics506

Bioinformática

Bio Workflows Neoantigen Pipeline

End-to-end neoantigen discovery from somatic variants to ranked vaccine candidates. Integrates HLA typing, MHC binding prediction, pVACtools neoantigen calling, and immunogenicity scoring. Use when identifying tumor neoantigens for personalized vaccine design or checkpoint biomarkers.

GPTomics506

Académico

Clinical Decision Support Documents

Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based guidelines with decision algorithms). Supports GRADE evidence grading, statistical analysis (hazard ratios, survival curves, waterfall plots), biomarker integration, and regulatory compliance. Outputs publication-ready LaTeX/PDF format optimized for drug development, clinical research, and evidence synthesis.

jimmc414498

Académico

Peer Review

Systematic peer review toolkit. Evaluate methodology, statistics, design, reproducibility, ethics, figure integrity, reporting standards, for manuscript and grant review across disciplines.

jimmc414498

Gestión de Proyectos

Skill Timeline

Research timeline planning for medical research projects. Invoke for timeline tasks.

benbrastmckie437

Bioinformática

Structural Pharmacogenomics

Structural Pharmacogenomics - Link structure to pharmacogenomics: variant effect, protein structure change, drug binding, and clinical data. Use this skill for pharmacogenomics tasks involving get vep hgvs pred protein structure esmfold boltz binding affinity get pharmacogenomics info by drug name. Combines 4 tools from 3 SCP server(s).

Científicos médicos, excepto epidemiólogos

Científicos médicos, excepto epidemiólogos

Bio Clinical Databases Clinvar Lookup

Bio Clinical Databases Tumor Mutational Burden

Bio Longitudinal Monitoring

Bio Liquid Biopsy Pipeline

Bio Workflows Neoantigen Pipeline

Clinical Decision Support Documents

Peer Review

Skill Timeline

Structural Pharmacogenomics

Orphan Drug Analysis

Tcga Gene Expression

Toxicity Assessment

Gene Variant Drug Nexus

Tissue Specific Analysis

Systems Pharmacology

Drug Safety Profile

Virtual Screening

Epigenetics Drug

Drug Target Identification Pipeline

Compound To Drug Pipeline

Gene To Drug Pipeline

Drugsda Admet

Drug Screening Docking

Drug Interaction Checker

Disease Drug Landscape

Cancer Therapy Design

Disease Compound Pipeline

Antibody Drug Development

Atc Drug Classification

Biomarker Discovery