Microbiologists

Prokka Genome Annotation

Annotate prokaryotic genome assemblies (bacteria, archaea, viruses) with Prokka's BLAST/HMM-based pipeline. Identifies CDS, rRNA, tRNA, tmRNA, and signal peptides against Pfam, TIGRFAMs, and RefSeq databases. Produces GFF3, GenBank, protein FASTA, and TSV outputs. Use PGAP instead when submitting to NCBI GenBank; use Bakta for faster annotation with NCBI-compatible outputs on modern assemblies.

sulfierry1

Pharmacophore Modeling

Apply Pharmacophore Modeling in computational biology and life sciences. Use when analyzing biological data, developing therapeutics, or building bioinformatics pipelines. This skill covers methodologies, tools, and applications in pharmacophore modeling.

Molecular Docking

Apply Molecular Docking in computational biology and life sciences. Use when analyzing biological data, developing therapeutics, or building bioinformatics pipelines. This skill covers methodologies, tools, and applications in molecular docking.

Metagenomics

Apply Metagenomics in computational biology and life sciences. Use when analyzing biological data, developing therapeutics, or building bioinformatics pipelines. This skill covers methodologies, tools, and applications in metagenomics.

Admet Prediction

Apply Admet Prediction in computational biology and life sciences. Use when analyzing biological data, developing therapeutics, or building bioinformatics pipelines. This skill covers methodologies, tools, and applications in admet prediction.

除錯

Variant Interpretation Report Followup

Use for report follow-up questions that need clarification of a specific variant, rsID, HGVS form, or competing interpretation.

povilaskarvelis1

學術

Aubrai Longevity

Answer questions about longevity, aging, lifespan extension, and anti-aging research using Aubrai's research engine with cited sources.

LJT-5201

計算化學

Bio Applied Assembly Binning

Metagenomic assembly with MEGAHIT, contig binning with MetaBAT2, and MAG quality assessment with CheckM. Includes binning signals, multi-sample strategy, and MIMAG quality tiers.

數據工程

Replication And Research Hygiene

Supports replication, result handoff, and canonical research pipelines. Use when organizing empirical or quantitative research code, preparing tables and figures, or making work rerunnable by someone else.

meleantonio1

Bio Core Blast Searching

BLAST: Sequence Similarity Searching with BLAST+

Bio Applied Microbial Diversity

Microbial diversity analysis: alpha/beta diversity metrics, OTU/ASV methods, taxonomy assignment, and community comparison. Use when analyzing 16S amplicon or microbiome data.

Scikit Bio

Biological data toolkit. Sequence analysis, alignments, phylogenetic trees, diversity metrics (alpha/beta, UniFrac), ordination (PCoA), PERMANOVA, FASTA/Newick I/O, for microbiome analysis.

Mishit181

Scientific Cancer Genomics

がんゲノミクスポータル統合スキル。COSMIC (体細胞変異カタログ)、 cBioPortal (がんゲノミクスデータ解析)、DepMap (がん細胞依存性) の 3 大がんゲノミクスデータベースを統合した変異プロファイリング、変異シグネチャー解析、遺伝子依存性 (essentiality) 評価、コピー数変化・がん種横断解析パイプライン。 13 の ToolUniverse SMCP ツールと連携。

Scientific Cell Line Resources

細胞株リソーススキル。Cellosaurus 細胞株データベース検索、 STR プロファイルマッチング、コンタミネーション検出、細胞株メタデータ (由来組織・疾患・種) 取得パイプライン。

Scientific Noncoding Rna

非コード RNA (ncRNA) 解析スキル。Rfam RNA ファミリー検索、 RNAcentral 統合 ncRNA データベース、共分散モデル、構造マッピング、系統樹解析パイプライン。

教育

Scientific Crispr Design

CRISPR gRNA 設計スキル。Cas9/Cas12a PAM 配列検索・オフターゲットスコアリング (CFD/MIT)・ CRISPRscan/Rule Set 2 活性予測・検証プライマー設計・ sgRNA スクリーニングライブラリ構築パイプライン。 TU 外スキル (Python ライブラリ + ローカル解析)。

Tracking Taxonomy Updates

Track and reconcile taxonomy updates across NCBI, GTDB, ICTV, and community eukaryote frameworks with versioned provenance.

fmschulz1

Galaxy Metagenomics

Guided metagenomics profiling pipeline on Galaxy -- taxonomic classification, functional profiling, and diversity analysis

dannon1

計算化學

Zinc Database

Access ZINC database for purchasable compounds, similarity searches, and 3D-ready structures for virtual screening.

ChatAndBuild1

數據工程

Opentargets Database

Query Open Targets Platform for target-disease associations, drug discovery, and tractability/safety data.

ChatAndBuild1

天文同物理

Scientific Image Analysis

科学画像解析スキル。顕微鏡画像のセグメンテーション（Otsu/Watershed/Felzenszwalb）、粒径分布解析、形態計測（面積・周囲長・真円度・アスペクト比）、テクスチャ解析（GLCM/LBP）、強度プロファイル、マルチチャネル蛍光画像合成の解析テンプレート。

Scientific Parasite Genomics

寄生虫ゲノミクススキル。PlasmoDB/VectorBase/ToxoDB REST API による寄生虫ゲノム検索・遺伝子情報・薬剤標的同定・比較ゲノミクス。直接 REST API 連携 (TU 外)。

計算化學

Scientific Drug Target Profiling

創薬ターゲットプロファイリングスキル。ToolUniverse / Open Targets / ChEMBL / UniProt を活用したドラッグターゲットインテリジェンス。ドラッガビリティ評価、安全性プロファイリング、ターゲット-疾患アソシエーション、競合パイプライン分析を統合的に実行。「ターゲット評価して」「druggability 分析して」「標的タンパク質を調べて」で発火。

除錯

Bio Applied Taxonomic Profiling

Taxonomic profiling of shotgun metagenomes: host decontamination, Kraken2 classification, Bracken abundance re-estimation

Bio Applied Qiime2 16s

16S rRNA amplicon analysis with QIIME2: DADA2 denoising, taxonomy assignment, alpha/beta diversity, and differential abundance. Use when analyzing 16S microbiome data.