Bioinformatics

Classify germline variants from VCF/BCF files according to the ACMG/AMP 2015 28-criteria evidence framework and generate clinical-grade interpretation reports with per-variant evidence audit trails and ACMG SF v3.2 secondary findings screening.

ClawBio724

Bioinformatics

Clinpgx

Query the ClinPGx API for pharmacogenomic gene-drug data, clinical annotations, CPIC guidelines, and FDA drug labels

ClawBio724

Bioinformatics

Pharmgx Reporter

Pharmacogenomic report from DTC genetic data (23andMe/AncestryDNA) — 12 genes, 31 SNPs, 51 drugs

ClawBio724

Bioinformatics

Illumina Bridge

Import DRAGEN-exported Illumina result bundles into ClawBio for local tertiary analysis and downstream routing.

ClawBio724

Bioinformatics

Nutrigx Advisor

Personalised nutrition report from consumer genetic data (23andMe, AncestryDNA, VCF) — interrogates nutritionally-relevant SNPs and generates actionable dietary guidance, all computed locally.

ClawBio724

Bioinformatics

Repro Enforcer

Export any bioinformatics analysis as a reproducible bundle with Conda environment, Singularity container definition, and Nextflow pipeline.

ClawBio724

Bioinformatics

Rnaseq De

Differential expression analysis for bulk RNA-seq and pseudo-bulk count matrices with QC, PCA, and contrast testing.

ClawBio724

Bioinformatics

Struct Predictor

Protein structure prediction with Boltz-2. Accepts YAML inputs (single protein or multi-chain complex), runs boltz predict, extracts per-residue pLDDT and PAE confidence, and writes a markdown report with figures.

ClawBio724

Bioinformatics

Hla Typing

HLA allele typing from WGS/WES VCF data

ClawBio724

Bioinformatics

Variant Annotation

Annotate VCF variants with Ensembl VEP REST, ClinVar significance, gnomAD/population frequency context, and prioritized variant ranking.

ClawBio724

Bioinformatics

Scrna Orchestrator

Local Scanpy pipeline for single-cell RNA-seq QC, optional doublet detection, clustering, marker discovery, optional CellTypist annotation, optional latent downstream mode from integrated.h5ad/X_scvi, and optional dataset-level plus within-cluster contrastive marker analysis from raw-count .h5ad or 10x Matrix Market input.

ClawBio724

Bioinformatics

Gwas Lookup

Federated variant lookup across 9 genomic databases — GWAS Catalog, Open Targets, PheWeb (UKB, FinnGen, BBJ), GTEx, eQTL Catalogue, and more.

ClawBio724

Bioinformatics

Diff Visualizer

Rich downstream visualisation and reporting for bulk RNA-seq differential expression and scRNA marker/contrast outputs.

ClawBio724

Bioinformatics

Vcf Annotator

Annotate VCF variants with VEP, ClinVar, gnomAD frequencies, and ancestry-aware context. Generates prioritised variant reports.

ClawBio724

Bioinformatics

Genome Compare

Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture

ClawBio724

Bioinformatics

Claw Ancestry Pca

Ancestry decomposition PCA against the Simons Genome Diversity Project

ClawBio724

Bioinformatics

Archaic Introgression

Detect Neanderthal and Denisovan introgression segments from modern human genomes

ClawBio724

Bioinformatics

Scrna Embedding

Local scVI/scANVI-based single-cell latent embedding and batch-aware integration from raw-count .h5ad or 10x Matrix Market input, with stable integrated AnnData export for downstream latent analysis.

ClawBio724

Bioinformatics

Recombinator

Produce offspring genomes from parent pairs via meiotic recombination, mutation, and clinical evaluation

ClawBio724

Bioinformatics

Soul2dna

Compile SOUL.md character profiles into synthetic diploid genomes (.genome.json) via trait-to-allele mapping

ClawBio724

Bioinformatics

De Summary

Summarise pre-computed differential expression results with ranked gene lists, biological themes, and publication-ready interpretation.

ClawBio724

Bioinformatics

Vector Database Engineer

Expert in vector databases, embedding strategies, and semantic search implementation. Masters Pinecone, Weaviate, Qdrant, Milvus, and pgvector for RAG applications, recommendation systems, and similar

rmyndharis660

Bioinformatics

Swarm Coordination

Multi-agent coordination patterns for OpenCode swarm workflows. Use when work benefits from parallelization or coordination. Covers: decomposition, worker spawning, file reservations, progress tracking, and review loops.

joelhooks633

Bioinformatics

Swarm Coordination

Multi-agent coordination patterns for OpenCode swarm workflows. Use when work benefits from parallelization or coordination. Covers: decomposition, worker spawning, file reservations, progress tracking, and review loops.

joelhooks633

Bioinformatics

Ncbi Entrez

Query NCBI E-utilities for GenBank sequences, gene info, SNPs, ClinVar variants, and literature links. Use when the user needs nucleotide/protein sequences from GenBank, gene summaries, variant data, or cross-database links. NOT for protein annotations (use UniProt), 3D structures (use PDB), or pathway mapping (use KEGG).

beita6969583

Bioinformatics

Performs bioinformatics analyses including pathway enrichment, gene ontology analysis, protein-protein interaction networks, multi-omics integration, and biological sequence database querying; trigger when users discuss gene sets, biological pathways, functional annotation, or omics data integration.

beita6969583

Bioinformatics

Genomics Analysis

Orchestrates a genomics analysis workflow from gene query through expression analysis to pathway enrichment. Use when investigating gene function, analyzing expression data, or performing pathway-level interpretation. NOT for pure protein structure modeling or drug-target interaction analysis.

beita6969583

Bioinformatics

Methylation Clock

Bioinformatics

Methylation Clock

Claw Metagenomics

Drug Photo

Clinical Variant Reporter

Clinpgx

Pharmgx Reporter

Illumina Bridge

Nutrigx Advisor

Repro Enforcer

Rnaseq De

Struct Predictor

Hla Typing

Variant Annotation

Scrna Orchestrator

Gwas Lookup

Diff Visualizer

Vcf Annotator

Genome Compare

Claw Ancestry Pca

Archaic Introgression

Scrna Embedding

Recombinator

Soul2dna

De Summary

Vector Database Engineer

Swarm Coordination

Swarm Coordination

Ncbi Entrez

Bioinformatics

Genomics Analysis