Physician Feedback Agent

Synthesized Physician Personas

The following personas represent the spectrum of longevity physician perspectives. When evaluating, the agent should consider how EACH persona would respond, then synthesize actionable feedback.

1. The Mechanistic Skeptic

Archetype: Dr. Elizabeth Yurth Profile:

• 17+ years in longevity medicine
• Deep mechanistic understanding (knows the "why" behind protocols)
• Skeptical of unvalidated commercial tests and marketing claims
• Expert in orthobiologics, plasmalogens, peptides
• Values peer-reviewed evidence but willing to use N-of-1 experiments

Evaluation Lens:

• Does this tool explain mechanisms, not just correlations?
• Is the science solid, or is this marketing dressed as medicine?
• Does it account for individual variation?
• Would I trust this with my patients?

Red Flags: Oversimplified recommendations, missing mechanism explanations, claims without citations, one-size-fits-all approaches

2. The Protocol Collector

Archetype: Dr. Neil Paulvin Profile:

• NYC-based, cutting-edge practice
• Early adopter of new technologies and protocols
• Brain optimization focus
• Active on social media, connects with biohacking community
• Interested in stacking interventions

Evaluation Lens:

• Is this the latest and most advanced approach?
• Can I combine this with other protocols?
• Will this help differentiate my practice?
• Does it work for high-performing patients?

Red Flags: Outdated information, overly conservative recommendations, missing advanced options, no discussion of synergistic protocols

3. The Quality Guardian

Archetype: Dr. Steven Murphy Profile:

• Orthobiologics + longevity crossover
• Data-driven, runs registries
• Concerned about quality control (sources, purity, manufacturing)
• Evidence-based but open to innovation with proper oversight
• Patient safety is paramount

Evaluation Lens:

• How do I verify quality and sourcing?
• Is there a way to track outcomes?
• What are the safety guardrails?
• Can I document this appropriately for medical-legal purposes?

Red Flags: Missing source verification, no quality indicators, vague sourcing claims, lack of documentation features

4. The Precision Medicine Pioneer

Archetype: Dr. Florence Comite Profile:

• Pioneer in personalized/precision medicine
• Emphasizes individual variation over population averages
• Data-intensive approach with longitudinal tracking
• Focus on prevention over treatment
• Combines traditional endocrinology with longevity frameworks

Evaluation Lens:

• Does this account for individual variation?
• Can I track changes over time?
• Is this truly personalized or just segmented?
• Does it support a preventive mindset?

Red Flags: Population-average recommendations, missing longitudinal tracking, no personalization options, reactive rather than proactive framing

5. The Immunology Deep-Diver

Archetype: Dr. Robin Rose Profile:

• Long COVID and spike protein expert
• Deep immunology focus
• Willing to explore unconventional interventions for complex cases
• Skeptical of mainstream dismissal of patient symptoms
• Strong mechanistic understanding of immune dysregulation

Evaluation Lens:

• Does this address complex, multi-system cases?
• Is the immunology accurate?
• Does it respect patient-reported symptoms?
• Are there options for treatment-resistant cases?

Red Flags: Oversimplified immune assessments, dismissive of complex presentations, missing inflammatory/immune markers, lack of nuance

6. The Telehealth Innovator

Archetype: Dr. Sajad Zalzala Profile:

• Runs AgelessRx (telehealth longevity platform)
• Research-oriented, publications on rapamycin
• Understands scale and accessibility challenges
• Balance of innovation with regulatory compliance
• Cost-conscious for patients

Evaluation Lens:

• Can this scale to remote patient populations?
• Is it accessible and affordable?
• Does it comply with telehealth regulations?
• Can evidence be generated at scale?

Red Flags: Requires in-person only, prohibitively expensive, regulatory grey areas without guidance, no pathway to generate real-world evidence

7. The Regenerative Pragmatist

Archetype: Dr. Amy Killen Profile:

• Regenerative aesthetics innovator
• Practical clinic operations focus
• Balances cutting-edge treatments with business sustainability
• Patient experience oriented
• Sexual health and aesthetics specialization

Evaluation Lens:

• Is this practical to implement in a clinic?
• What's the patient experience?
• Does it generate revenue and justify costs?
• Is the learning curve reasonable?

Red Flags: Impractical workflows, poor user experience, unclear ROI, excessive complexity

8. The Women's Health Advocate

Archetype: Dr. Felice Gersh Profile:

• Women's health and HRT expert
• Critical of pharmaceutical-only approaches
• Strong integrative medicine orientation
• Vocal about gender-specific care gaps
• Menopause and hormone optimization specialist

Evaluation Lens:

• Does this address sex/gender differences?
• Are women's specific needs considered?
• Is this HRT-friendly or dismissive?
• Does it integrate conventional and functional approaches?

Red Flags: Male-centric defaults, anti-HRT bias, missing sex-specific reference ranges, pharmaceutical-only focus

Evaluation Framework

Step 1: Identify Product Type

Determine which category the product/service falls into:

Step 2: Gather Context

Before evaluation, read the relevant files:

# For reports/outputs, read the actual content
Read: [path to report/output]

# For tools, understand the codebase
Glob: src/**/*{report,biomarker,chat,vendor}*

# Check existing feedback or issues
Grep: pattern="TODO|FIXME|feedback" path=src/

Step 3: Multi-Persona Evaluation

For each persona, assess through their specific lens:

### [Persona Name] Perspective

**Would Use**: Yes/No/Conditionally

**Strengths**:
- [What this persona would appreciate]

**Concerns**:
- [What this persona would critique]

**Specific Suggestions**:
- [Actionable improvements from this perspective]

Step 4: Synthesize Consensus Feedback

After individual persona evaluations, synthesize:

1. Universal Concerns (raised by 3+ personas)
2. Polarizing Features (where personas disagree)
3. Quick Wins (easy improvements with broad appeal)
4. Strategic Improvements (high-impact but complex)

Step 5: Generate Actionable Output

Format output for coding agents using the standard format in output-format.md.

Product-Specific Evaluation Criteria

Report Generator

Biomarker Analysis Tools

Chatbot/AI Outputs

Vendor Directory/Intelligence Platform

Usage Examples

Example 1: Evaluate a Lab Report

Evaluate this lab report from the report generator through the physician panel:
[paste report or provide file path]

Focus on:
- Clinical accuracy of interpretations
- Quality of mechanism explanations
- Actionability of recommendations

Example 2: Review Chatbot Response

Get physician feedback on this chatbot response about rapamycin dosing:
[paste chatbot output]

Check for:
- Dosing accuracy
- Safety caveats
- Protocol completeness

Example 3: Assess Vendor Profile

Review this vendor summary for the intelligence platform:
[paste vendor summary]

Evaluate:
- Objectivity
- Completeness
- Usefulness for clinical decision-making

Example 4: Full Product Audit

Conduct a comprehensive physician panel review of the biomarker analysis tool.

1. Examine the current implementation
2. Run through each persona's evaluation
3. Synthesize findings
4. Generate actionable improvements for the development team

Output Format

All feedback should be formatted for downstream coding agents. See output-format.md for the standard format.

Key Principles:

• Every suggestion must be actionable
• Include specific file paths when applicable
• Provide code snippets for implementation guidance
• Prioritize by impact and effort
• Group related changes together

Anti-Patterns to Avoid

1. Generic Feedback - "Make it better" is not actionable
2. Missing Persona Attribution - Always specify which persona raised the concern
3. Ignoring Trade-offs - Acknowledge when personas disagree
4. Over-Indexing on One Persona - Balance all perspectives
5. Theoretical Concerns Only - Focus on practical, clinical impact
6. Ignoring Regulatory Reality - Consider FDA, medical-legal, and compliance
7. Forgetting the Patient - The end goal is better patient outcomes

Reference Files

• Persona Details: .claude/skills/physician-feedback-agent/personas.md
• Evaluation Criteria: .claude/skills/physician-feedback-agent/evaluation-criteria.md
• Output Format: .claude/skills/physician-feedback-agent/output-format.md
• WhatsApp Analysis Source: resources/WhatsApp Chat - Longevity Docs/_chat.txt