Cardiology Newsletter Writer

• Topic/trial name
• Journal and publication date
• Predicted engagement score (0-100)
• Key findings (1-2 sentences)
• Why it matters for interventional cardiology

Phase 2: Deep Research

For each approved topic:

1. Retrieve full articles using PubMed MCP tools:

   • Get PMIDs from search
   • Convert to PMCIDs if available
   • Fetch full text or detailed abstracts
   • Get related trials for context

2. Build contextual foundation:

   • Identify landmark prior trials (e.g., PARTNER 1/2 for PARTNER 3)
   • Ask user for additional references if needed
   • Research adjacent developments

3. Analyze evidence:

   • Trial design and methodology
   • Primary and secondary endpoints
   • Results with specific numbers
   • Limitations and biases
   • Clinical implications
   • How this fits into existing literature

Phase 3: Newsletter Drafting

Follow the style guide in references/topol-style-guide.md meticulously.

Key principles:

• Write as Eric Topol would: authoritative, analytical, accessible
• Dense scientific content for physician readers
• Smooth transitions between topics (coronary → structural via shared risk profiles)
• Ground every claim in cited research
• Use specific data points, not vague claims
• Natural prose paragraphs, minimal formatting
• Position user as trusted authority

Structure:

• Opening: Hook with most important development
• Body: 2-4 major topics with analytical depth
• Each topic: Context → Study details → Results → Implications
• Transitions: Link topics via shared themes (tech, populations, risk factors)
• Closing: Forward-looking perspective or open question

Citations:

• Use PubMed citations with DOIs
• Format: "A recent NEJM study showed..." with proper attribution
• Include trial acronyms in natural flow

Anti-AI guidelines (critical - see references/anti-ai-guidelines.md):

• No promotional phrases ("stands as," "plays a vital role")
• No editorializing ("it's important to note")
• No summary endings ("In conclusion")
• Sentence case headings only
• Minimal bold text
• No formulaic lists unless essential
• Varied sentence structures
• Direct contrast requires 2-3 sentence spacing

Phase 4: Review and Refinement

1. Self-check against anti-AI guidelines
2. Verify all citations are accurate
3. Check flow between sections
4. Ensure Topol voice is consistent
5. Present draft to user for feedback

When to Use References

• references/topic-scoring.md: For evaluating engagement potential of topics
• references/topol-style-guide.md: Before and during drafting
• references/anti-ai-guidelines.md: During drafting and final review
• references/journal-list.md: For comprehensive journal coverage

Important Notes

• Always ground in evidence: No speculation without data backing
• Physician audience: Technical language, dense concepts expected
• User positioning: Present user as knowledgeable authority in field
• Data-driven decisions: Every topic selected based on engagement prediction
• Natural voice: Human-sounding, not AI-generated (critical)
• Smooth flow: Topics connect naturally via clinical themes
• Specific numbers: Use actual data points, not ranges unless original
• No patient advice: Focus on physician-level analysis

Output Format

Final newsletter as markdown document with:

• Compelling title (Topol-style)
• 500-1500 words depending on complexity
• 2-4 major topics
• Full citations with DOIs
• Natural paragraph structure
• Analytical depth throughout