Toxicology Calculator

Common Toxicant Reference

Chocolate (dogs):

• Theobromine content varies by type: white (~0.25 mg/g), milk (~2.4 mg/g), dark (~5.5 mg/g), baking (~16 mg/g), cocoa powder (~28.5 mg/g)
• Mild signs (GI): 20 mg/kg theobromine
• Cardiac signs: 40-50 mg/kg
• Seizures: 60+ mg/kg
• Lethal dose (LD50): ~100-200 mg/kg
• Theobromine half-life in dogs: ~17.5 hours

Xylitol (dogs):

• Hypoglycemia threshold: 0.1 g/kg (100 mg/kg); some reports suggest sensitivity at doses as low as 0.05 g/kg. Treat any significant xylitol ingestion as an emergency.
• Hepatotoxicity threshold: 0.5 g/kg (500 mg/kg)
• Onset of hypoglycemia: 30-60 minutes (can be delayed with some xylitol-containing products)
• Note: Cats appear less susceptible but data is limited; increasing prevalence in sugar-free foods, dental products, and peanut butters

Grapes/Raisins (dogs):

• No established safe dose. Any ingestion in dogs should be treated as potentially toxic.
• Toxic dose is idiosyncratic and unpredictable
• Raisins are more concentrated than grapes by weight
• Can cause acute kidney injury

Lilies (cats):

• ALL parts of true lilies (Lilium and Hemerocallis species) are nephrotoxic to cats
• No safe dose. Even pollen exposure or water from a lily vase can be fatal.
• Causes acute kidney injury within 24-72 hours
• Dogs are NOT affected by lily nephrotoxicity

Ethylene glycol (all species):

• Lethal dose dogs: ~6.6 mL/kg
• Lethal dose cats: ~1.5 mL/kg (cats are 4x more sensitive)
• Treatment window: 8-12 hours (dogs), 3 hours (cats) for antidote efficacy

THC / Marijuana (dogs primarily):

• Dogs are significantly more sensitive than humans; toxicity reported at 0.5-3 g/kg of marijuana plant material
• Edibles (brownies, gummies, butter) are the most common exposure route and may contain additional toxicants (chocolate, xylitol)
• Clinical signs: Ataxia, urinary incontinence, mydriasis, bradycardia, hypothermia, stupor. Onset 30-90 minutes (edibles may be delayed).
• Severe cases: Seizures, coma, death (rare but reported, especially with concentrated products)
• Treatment: Supportive care, IV fluids, anti-emetics (if early), lipid emulsion therapy for severe cases

Macadamia nuts (dogs):

• Toxic dose: 2.4-62.4 g/kg (wide range; individual sensitivity varies)
• Clinical signs: Weakness (especially hindlimb), vomiting, tremors, hyperthermia. Onset 6-12 hours.
• Duration: Self-limiting, typically resolves within 24-48 hours
• Treatment: Supportive; rarely fatal but causes significant distress. Combined macadamia + chocolate ingestion increases severity.

Workflow

1. Identify the toxicant. What did the animal ingest? Resolve brand names to active ingredients where possible.

2. Identify the species. MANDATORY. Toxicity is species-dependent.

3. Gather quantitative data:

   • Patient body weight (kg)
   • Amount ingested (grams, mL, number of items, or "unknown")
   • Time since ingestion
   • If chocolate: type of chocolate (milk, dark, baking, cocoa powder)

4. Calculate dose per kilogram. Convert the amount ingested to mg/kg or g/kg of the toxic compound.

5. Stratify risk:

   • No concern: Dose below any toxic threshold for this species
   • Monitor: Dose in range where mild signs possible; home monitoring may be appropriate
   • Treat: Dose in range where clinical signs expected; veterinary care recommended
   • Critical: Dose at or above potentially lethal range; emergency veterinary care immediately

6. Assess decontamination window:

   • Emesis generally effective within 1-2 hours of ingestion (contraindicated in some situations)
   • Activated charcoal may help within 1-4 hours depending on substance
   • Note contraindications to emesis: corrosives, hydrocarbons, sharp objects, seizuring patient, brachycephalic breeds (higher aspiration risk)

7. Provide initial guidance and recommend contacting a veterinarian or the ASPCA Animal Poison Control Center (888-426-4435) or Pet Poison Helpline (855-764-7661).

Output Format

## Toxicity Assessment: [Substance] in [Species]

**Patient:** [Weight] kg [Species/Breed]
**Ingested:** [Amount] of [Substance]
**Calculated dose:** [X mg/kg] of [toxic compound]
**Time since ingestion:** [X hours]

**Risk Level:** [NO CONCERN / MONITOR / TREAT / CRITICAL]

**Toxic thresholds for [species]:**
- Mild signs at: [X mg/kg]
- Serious signs at: [X mg/kg]
- Potentially lethal at: [X mg/kg]
- Patient's dose: [X mg/kg] -- [above/below] [threshold]

**Expected clinical signs at this dose:**
- [List expected signs]
- [Expected onset timing]

**Decontamination:**
- Emesis: [Recommended/Not recommended] -- [reason]
- Activated charcoal: [Recommended/Not recommended]

**Action:** [Specific recommendation]

**Contact:** ASPCA Animal Poison Control: 888-426-4435 | Pet Poison Helpline: 855-764-7661

Limitations

• Calculations are based on published toxic dose ranges. Individual animals may be more or less sensitive.
• "Amount ingested" is often estimated. When uncertain, assume worst-case.
• This skill provides initial risk assessment, not treatment protocols. Treatment decisions require veterinary professional judgment.
• Some toxicants (grapes/raisins) have idiosyncratic toxicity with no reliable dose-response relationship.
• Exotic species toxicology data is extremely limited for most substances.