Biotech Pitch Deck Narrative

❌ Do NOT use when:

• Scientific conference presentations → Use technical language
• Regulatory submission documents → Use formal FDA/EMA formats
• Internal R&D team communications → Use full scientific detail
• Patent applications → Use precise legal/scientific terminology
• Patient-facing materials → Use lay-summary-gen

Integration:

• Upstream: market-access-value (commercial assessment), competitor-trial-monitor (competitive landscape)
• Downstream: business-model-canvas (strategy development), investor-relations-prep (ongoing communications)

Core Capabilities

1. Science-to-Business Translation

Convert technical concepts into investor-friendly language:

from scripts.narrative_engine import BiotechNarrativeEngine

engine = BiotechNarrativeEngine()

# Translate technical description
translation = engine.translate_science(
    technical_description="""
    Our proprietary AAV9-based gene therapy utilizes a codon-optimized 
    transgene under control of a liver-specific promoter to restore 
    functional enzyme in patients with MPS I deficiency.
    """,
    audience="generalist_vc",
    preserve_accuracy=True
)

print(translation.business_narrative)
# "One-time gene therapy delivering a functional copy of the missing enzyme, 
#  potentially curing MPS I rather than managing symptoms"

Translation Strategies:

2. Narrative Architecture

Structure pitch deck flow for maximum impact:

# Generate complete narrative arc
narrative = engine.build_narrative(
    company_stage="series_b",
    science_type="gene_therapy",
    clinical_stage="phase_2",
    target_market="rare_disease",
    key_differentiation="one_time_cure"
)

# Access each component
print(narrative.hook)           # Opening grab
print(narrative.problem)        # Market pain point
print(narrative.solution)       # Your approach
print(narrative.traction)       # Validation to date
print(narrative.ask)            # Funding request

Narrative Structure:

1. Hook (30 seconds): Why this, why now, why you
2. Problem ($B+ market): Unmet medical need, current standard limitations
3. Solution: Your technology/platform, mechanism of action
4. Traction: Clinical data, partnerships, validation
5. Market: Size, competition, your advantage
6. Team: Track record, why you'll succeed
7. Ask: Funding amount, use of proceeds, milestones

3. Stage-Specific Optimization

Calibrate message depth for funding round:

# Optimize for different stages
seed_narrative = engine.optimize_for_stage(
    base_narrative=narrative,
    stage="seed",
    focus="team_and_vision"  # Seed cares about team and big idea
)

series_a_narrative = engine.optimize_for_stage(
    base_narrative=narrative,
    stage="series_a",
    focus="proof_of_concept"  # Series A needs validation
)

ipo_narrative = engine.optimize_for_stage(
    base_narrative=narrative,
    stage="ipo",
    focus="commercial_readiness"  # IPO requires near-term revenue
)

Stage Requirements:

4. Investor Audience Calibration

Adapt tone and depth for different investor types:

# Calibrate for specific investor
calibrated = engine.calibrate_for_audience(
    narrative=narrative,
    investor_type="healthcare_vc",  # vs "generalist_vc" or "pharma_corp"
    technical_depth="moderate",      # Depth of scientific detail
    risk_tolerance="high"            # Early vs late stage framing
)

Investor Types:

• Generalist VC: Focus on market size, business model, team pedigree
• Healthcare VC: Balance science rigor with commercial potential
• Pharma BD: Emphasize strategic fit, validation data, partnership potential
• Public Market: Highlight near-term catalysts, revenue projections, risk mitigation

Common Patterns

Pattern 1: Clinical-Stage Therapeutics

Scenario: Phase 2 biotech raising Series B.

# Generate complete pitch narrative
python scripts/main.py \
  --science "Small molecule inhibitor targeting mutant KRAS G12C" \
  --stage "phase_2" \
  --indication "lung_cancer" \
  --data "ORR 45%, median PFS 6.5 months" \
  --competition "Mirati, J&J" \
  --output series_b_narrative.json

Narrative Elements:

• Problem: KRAS mutations in 30% of cancers; previously "undruggable"
• Solution: First-in-class covalent inhibitor with superior selectivity
• Traction: Phase 2 data showing 45% response rate, durable responses
• Market: $15B+ opportunity across multiple tumor types
• Differentiation: Best-in-class potency, favorable safety profile
• Ask: $75M to complete Phase 3 and prepare NDA

Pattern 2: Platform Company

Scenario: Novel delivery platform company raising seed.

platform_narrative = engine.generate_platform_narrative(
    platform_technology="Lipid nanoparticle for CNS delivery",
    differentiator="Crosses BBB with 50x improvement over existing LNPs",
    applications=["Alzheimer's", "Parkinson's", "brain_cancer"],
    stage="seed",
    target="platform_value_creation"
)

Platform Story Arc:

• Platform Thesis: Solving delivery problem unlocks multiple indications
• Validation: Proof-of-mechanism in 2+ disease models
• Breadth: Pipeline across CNS, oncology, rare disease
• **Partnership Appeal": Pharma interest in accessing CNS targets
• Scalability: Manufacturing platform supports multiple assets

Pattern 3: MedTech Device

Scenario: Surgical robotics company Series A.

device_narrative = engine.generate_device_narrative(
    device_type="surgical_robot",
    clinical_benefit="50% reduction in complications, 30% faster recovery",
    regulatory_path="510k_de_novo",
    reimbursement="CPT_code_established",
    stage="series_a"
)

Device-Specific Elements:

• Clinical Evidence: Superior outcomes vs. standard of care
• Economic Value: Cost savings to healthcare system
• Regulatory Clarity: Clear FDA pathway, reimbursement strategy
• Adoption Strategy: Training, support, key opinion leader engagement

Pattern 4: Pharma Partnership Pitch

Scenario: Out-licensing asset to big pharma.

# Generate BD materials
python scripts/main.py \
  --mode partnership \
  --asset "Phase 2 ready asset" \
  --indication "NASH" \
  --data_package "Phase 1b complete, biomarker validated" \
  --partner_profile "novo_nordisk" \
  --output bd_presentation.json

Partnership Framing:

• Strategic Fit: Complements partner's metabolism franchise
• Validation: De-risked with human proof-of-mechanism
• Value Creation: $500M+ peak sales potential
• Deal Structure: Flexible partnership terms proposed

Complete Workflow Example

Building comprehensive fundraising materials:

from scripts.narrative_engine import BiotechNarrativeEngine
from scripts.slide_generator import SlideGenerator
from scripts.qa_prep import QAPreparation

# Initialize
engine = BiotechNarrativeEngine()
slides = SlideGenerator()
qa = QAPreparation()

# Step 1: Generate core narrative
narrative = engine.build_narrative(
    company_stage="series_a",
    therapeutic_area="oncology",
    modality="cell_therapy",
    clinical_stage="phase_1",
    key_differentiation="allogeneic_off_the_shelf"
)

# Step 2: Create slide-by-slide guidance
slide_guide = slides.generate_guide(
    narrative=narrative,
    n_slides=12,
    include_visual_suggestions=True
)

# Step 3: Prepare Q&A
qa_prep = qa.generate_qa(
    narrative=narrative,
    investor_type="healthcare_vc",
    depth="comprehensive"
)

# Step 4: Export complete package
engine.export_package(
    narrative=narrative,
    slides=slide_guide,
    qa=qa_prep,
    output_dir="series_a_pitch_package/"
)

Quality Checklist

Narrative Quality:

• Opening hook grabs attention in 30 seconds
• Problem is a $B+ market with clear unmet need
• Solution is differentiated vs. competition
• Traction validates technical and commercial hypotheses
• Team has relevant track record
• Ask is specific with clear milestones

Translation Accuracy:

• Scientific claims remain accurate after simplification
• No misleading statements or exaggerated claims
• Risk factors disclosed appropriately
• Regulatory pathway is realistic
• Market size assumptions are defensible

Investor Alignment:

• Appropriate for stage and investor type
• Addresses likely investor concerns proactively
• Financial projections are reasonable
• Exit strategy is credible

Before Presentation:

• CRITICAL: Legal review of all claims
• CRITICAL: Scientific accuracy check by domain expert
• Rehearsed with feedback from experienced biotech investors
• Backup slides prepared for detailed questions

Common Pitfalls

Translation Errors:

• ❌ Oversimplification → "Our drug cures cancer" (misleading)

  • ✅ "Our drug showed tumor shrinkage in 40% of patients"

• ❌ Jargon overload → Technical terms without explanation

  • ✅ Use analogies: "Like a molecular GPS guiding drugs to tumors"

• ❌ Hiding risks → No mention of side effects or competition

  • ✅ Acknowledge risks with mitigation strategies

Narrative Mistakes:

• ❌ Technology in search of problem → Cool science, no market

  • ✅ Start with problem, solution follows naturally

• ❌ Ignoring competition → "We have no competitors"

  • ✅ Acknowledge competition, explain differentiation

• ❌ Unrealistic projections → $10B revenue in Year 3

  • ✅ Conservative estimates with clear assumptions

Stage Mismatch:

• ❌ Seed deck with Phase 3 projections → Too far ahead

  • ✅ Match milestones to stage-appropriate timelines

• ❌ IPO presentation to seed investors → Wrong focus

  • ✅ Tailor depth and emphasis to investor sophistication

References

Available in references/ directory:

• vc_presentation_best_practices.md - Venture capital pitch guidelines
• biotech_valuation_models.md - Valuation methodologies by stage
• regulatory_pathway_guides.md - FDA/EMA approval timelines
• market_sizing_methodologies.md - TAM/SAM/SOM calculations
• investor_question_bank.md - Common Q&A by investor type
• competitive_landscape_templates.md - Positioning frameworks

Scripts

Located in scripts/ directory:

• main.py - CLI interface for narrative generation
• narrative_engine.py - Core story architecture
• science_translator.py - Technical to business translation
• slide_generator.py - Deck structure and visual guidance
• qa_preparation.py - Investor Q&A preparation
• competitive_analyzer.py - Market positioning analysis
• risk_framer.py - Risk mitigation messaging
• stage_optimizer.py - Funding round calibration

Limitations

• Not Financial Advice: Cannot provide investment recommendations
• Regulatory Compliance: Does not ensure SEC or other regulatory compliance
• Market Specificity: May not capture niche investor preferences
• Real-Time Adaptation: Cannot adjust to live investor reactions
• Confidentiality: Does not handle material non-public information protection
• Legal Review: All materials require legal counsel review before use

Parameters

*Required depending on subcommand

Usage

Basic Usage

# Generate narrative from science description
python scripts/main.py generate --science "CRISPR gene therapy for sickle cell" --stage series-a --audience healthcare-vc

# Rewrite specific section
python scripts/main.py rewrite --section technology --content "We use AAV vectors..." --audience generalist-vc

# Analyze existing pitch deck
python scripts/main.py analyze --input pitch.pptx --stage series-a

Risk Assessment

Security Checklist

• No hardcoded credentials or API keys
• No unauthorized file system access
• Output does not expose sensitive information
• Prompt injection protections in place
• Error messages sanitized
• Script execution in sandboxed environment

Prerequisites

# Python 3.7+
# No additional packages required (uses standard library)

Evaluation Criteria

Success Metrics

• Successfully generates pitch narratives
• Adapts content to different investor types
• Rewrites technical content for business audiences
• Provides stage-appropriate messaging

Test Cases

1. Generate Narrative: Science description → Complete pitch narrative
2. Rewrite Section: Technical content → Business-friendly version
3. Audience Adaptation: Same content for different VC types

Lifecycle Status

• Current Stage: Draft
• Next Review Date: 2026-03-06
• Known Issues: Help text in Chinese
• Planned Improvements:
  • Translate all interface text to English
  • Add more investor personas
  • Enhance narrative templates

💼 Business Note: Successful biotech fundraising requires balancing scientific credibility with business appeal. This tool helps structure narratives, but the underlying science and team execution ultimately determine success. Always maintain integrity—overpromising destroys credibility with sophisticated investors.