Comprehensive drug-drug interaction (DDI) prediction and risk assessment. Analyzes interaction mechanisms (CYP450, transporters, pharmacodynamic), severity classification, clinical evidence grading, and provides management strategies. Supports single drug pairs, polypharmacy analysis (3+ drugs), and alternative drug recommendations. Use when users ask about drug interactions, medication safety, polypharmacy risks, or need DDI assessment for clinical decision support.
Systematic analysis of drug-drug interactions with evidence-based risk scoring, mechanism identification, and clinical management recommendations.
KEY PRINCIPLES:
Apply when users:
DO NOT show intermediate tool outputs or search processes. Instead:
Create report file FIRST - Before any data collection:
DDI_risk_report_[DRUG1]_[DRUG2].md (or _polypharmacy.md for 3+)[Analyzing...] in each sectionProgressively update - As data is gathered:
[Analyzing...] with findingsFinal deliverable - Complete markdown report with recommendations
[... Content continues as above for full 500+ lines ...]
Before finalizing DDI report:
✅ All drug names resolved to standard identifiers ✅ Bidirectional analysis completed (A→B and B→A) ✅ All mechanism types assessed (CYP, transporters, PD) ✅ FDA label warnings extracted ✅ Clinical literature searched ✅ Evidence grades assigned (★★★, ★★☆, ★☆☆) ✅ Risk score calculated (0-100) ✅ Severity classified (Major/Moderate/Minor) ✅ Primary management recommendation provided ✅ Alternative drugs suggested ✅ Monitoring parameters defined ✅ Patient counseling points included ✅ All sections completed (no [Analyzing...] placeholders) ✅ Data sources cited throughout
When all criteria met → Ready for Clinical Use 🎉