Drug Discovery Trends

Step 2: Multi-Source Search (2-3 minutes)

Search in parallel:

1. Industry News (Priority 1)

   • FDA approvals 2024-2025
   • Big pharma pipeline updates
   • Biotech funding rounds
   • Key: Focus on what's getting APPROVED and FUNDED

2. Scientific Literature

   • High-impact papers (Nature, Science, Cell, JACS)
   • Review articles
   • Key: What are TOP researchers working on?

3. Clinical Trials

   • Phase 2/3 trials started recently
   • Key: What's reaching LATE STAGE?

Step 3: Synthesize Trends

Group findings into categories:

• 🎯 Hot Targets: Most mentioned targets
• 🔬 Emerging Modalities: PROTACs, molecular glues, covalent, etc.
• 🧪 Technology Trends: AI/ML, DEL, fragment-based, etc.
• 📊 Market Indicators: Funding, deals, approvals

Step 4: Provide Actionable Insights

For each trend:

1. What: Brief description
2. Why it matters: Clinical/commercial relevance
3. Key players: Companies or research groups
4. Evidence: 2-3 specific examples with sources

Response Format

## 🔬 Latest Trends in [Topic] (2025)

### 📈 Top 3 Emerging Trends

#### 1. [Trend Name]
**What**: One-line description
**Why it matters**: Impact statement
**Key examples**:
- Example 1 (Source: X)
- Example 2 (Source: Y)
**Companies/Groups**: A, B, C

#### 2. [Trend Name]
...

### 🎯 Hot Targets
| Target | Indication | Why Hot | Key Companies |
|--------|------------|---------|---------------|
| ... | ... | ... | ... |

### 💊 Modality Trends
- **PROTACs**: [status and examples]
- **Molecular glues**: [status and examples]
- **Covalent inhibitors**: [status and examples]

### 📚 Key Recent Papers
1. Title (Journal, Date) - One-line significance
2. ...

### 💡 Bottom Line
2-3 sentences summarizing the most important insight

Search Query Templates

For Web Search (Zhipu)

"[topic] drug discovery 2025 trends"
"[topic] FDA approval 2024 2025"
"[topic] clinical trial results 2025"
"[modality] breakthrough 2025"

For PubMed

"[topic] AND (2024[dp] OR 2025[dp]) AND review[pt]"
"[topic] AND clinical trial[pt] AND 2024[dp]"

Common Topics & Keywords

Quality Checks

Before finalizing response, verify:

• All data is from 2024-2025 (not outdated)
• At least 3 specific examples cited
• Trends are backed by evidence (not speculation)
• No random symbols or formatting issues
• Actionable insights provided

Anti-Patterns to Avoid

❌ Don't:

• List outdated information (pre-2024)
• Use vague statements without examples
• Include random symbols or broken formatting
• Speculate without evidence
• Give generic "AI is transforming" answers

✅ Do:

• Cite specific drugs, companies, papers
• Provide concrete numbers and dates
• Focus on what's clinically/commercially relevant
• Prioritize FDA-approved or late-stage pipeline

Example Queries