First supplement-drug interaction safety tool for AI agents. Evidence-based supplement safety intelligence with 805 FDA FAERS adverse event signals and CYP450 pathway analysis.
The first supplement-drug interaction safety tool purpose-built for AI agents. Provides evidence-based supplement safety intelligence covering 805 FDA FAERS adverse event signals and comprehensive CYP450 enzyme pathway analysis for herbal products, vitamins, and dietary supplements that are frequently omitted from standard drug interaction databases.
npx skills add Open-Medica/open-medical-skills --skill supplement-drug-interactions
Single supplement check:
Check interactions between St. John's Wort and oral contraceptives
Result: Significant interaction. St. John's Wort is a potent CYP3A4 inducer that can reduce ethinyl estradiol and progestin plasma concentrations by 40-60%, leading to contraceptive failure. Documented in multiple case reports of unplanned pregnancies. Recommendation: use alternative contraception or discontinue St. John's Wort.
Multi-supplement screening:
Patient takes: metoprolol 50mg BID, lisinopril 10mg daily
Supplements: CoQ10 200mg, magnesium glycinate 400mg, hawthorn berry extract
Screen for interactions.
Result: (1) CoQ10 — no significant interaction with either medication; may provide additive cardioprotective benefit. (2) Magnesium — monitor: high-dose magnesium may enhance the hypotensive effect of lisinopril; advise spacing doses. (3) Hawthorn berry — Caution: additive bradycardia and hypotension risk with metoprolol; monitor heart rate and blood pressure closely.
This skill is part of Open Medical Skills, a curated marketplace of medical AI skills maintained by physicians for physicians and the healthcare industry.