Drug Interaction Checker

Common Veterinary Drug Interactions

• NSAIDs + corticosteroids: Increased GI ulceration risk (especially in dogs)
• ACE inhibitors + potassium-sparing diuretics: Hyperkalemia risk
• Phenobarbital + many drugs: CYP450 enzyme inducer; decreases levels of concurrent drugs
• Ketoconazole/itraconazole + many drugs: CYP450 inhibitor; increases levels of concurrent drugs
• Metoclopramide + opioids: Antagonistic effects on GI motility
• Fluoroquinolones + divalent cations (sucralfate, antacids): Chelation reduces absorption
• Cisapride + azole antifungals: QT prolongation risk
• Selegiline (Anipryl) + serotonergic drugs (tramadol, SSRIs, TCAs): Serotonin syndrome risk. Selegiline is an MAO-B inhibitor used for canine cognitive dysfunction. Do not combine with tramadol, fluoxetine, clomipramine, or amitriptyline. Allow 2-week washout between discontinuation and starting a serotonergic drug.
• Metronidazole + phenobarbital: Phenobarbital induces metronidazole metabolism; may require dose adjustment
• Cyclosporine + ketoconazole: Ketoconazole intentionally used to reduce cyclosporine dose (cost-saving strategy in vet practice, but requires monitoring)

Output Format

## Drug Interaction Check: [Species]

**Medications:** [List all drugs]

**Interactions found:**

1. [Drug A] + [Drug B]
   - **Severity:** [Contraindicated/Major/Moderate/Minor]
   - **Mechanism:** [How they interact]
   - **Clinical effect:** [What could happen]
   - **Management:** [What to do about it]

**No interactions found between:** [List non-interacting pairs]

Limitations

• Veterinary drug interaction databases are less comprehensive than human databases. Many interactions are extrapolated from human data.
• Individual patient factors (hepatic/renal disease, age) affect interaction risk.
• Nutraceuticals and supplements may have undocumented interactions.
• This skill identifies known interactions; absence of a listed interaction does not guarantee safety.