Real-time drug-drug interaction detection with five-level severity classification (A/B/C/D/X). Checks for drug-disease, drug-dose, and drug-food interactions using FDA and clinical databases.
Real-time drug-drug interaction detection with five-level severity classification (A/B/C/D/X), modeled after the Lexicomp grading system. This skill checks for drug-disease contraindications, drug-dose range violations, and drug-food interactions by referencing FDA adverse event databases and peer-reviewed clinical pharmacology sources.
npx skills add Open-Medica/open-medical-skills --skill drug-interaction-checker
Checking a two-drug pair:
Check interaction between warfarin and fluconazole
Result: Severity X (Avoid Combination). Fluconazole is a potent CYP2C9 inhibitor that significantly increases warfarin plasma concentrations. Case reports document INR values exceeding 10 with concurrent use. If unavoidable, reduce warfarin dose by 25-50% and monitor INR every 2-3 days.
Screening a full medication list:
Screen the following regimen for interactions:
- Lisinopril 20mg daily
- Metformin 1000mg BID
- Atorvastatin 40mg daily
- Amlodipine 5mg daily
- Ibuprofen 600mg TID
Result: Severity C (Monitor Therapy) between lisinopril and ibuprofen: NSAIDs may reduce antihypertensive efficacy and increase risk of acute kidney injury, particularly in volume-depleted patients. Consider acetaminophen as an alternative analgesic.
This skill is part of Open Medical Skills, a curated marketplace of medical AI skills maintained by physicians for physicians and the healthcare industry.