Trial Eligibility Agent

Workflow

1. Acquire protocol: Pull eligibility text from ClinicalTrials.gov or sponsor PDF.
2. Normalize criteria: Break into atomic checks with AND/OR logic and thresholds.
3. Extract patient facts: Map narrative + FHIR data into canonical features (age, labs, ECOG, biomarkers).
4. Evaluate: Assign MET/NOT/UNKNOWN with cited evidence for each criterion, flag missing context explicitly.
5. Summarize: Present recommendation and highlight gating unknowns plus next-best actions.

Guardrails

• Never claim enrollment decisions; mark outputs as advisory.
• Cite direct patient evidence for every MET/NOT call; default to UNKNOWN rather than guessing.
• Respect PHI handling expectations—avoid storing raw notes outside secure paths.

Tooling & References

• Use README.md for API snippets (FHIR parsing, JSON schema) and dependency versions.
• Pair with Clinical/Trial_Matching/TrialGPT when retrieval/ranking is also needed.