Two-trace model for spike-timing-dependent plasticity (STDP). Model NMDA receptor activation and Ca2+ concentration traces. Reproduce pairwise STDP rules and triplet nonlinearities. Bridge phenomenological rules and detailed models.
An effective model for timing-dependent synaptic plasticity (STDP) using two interacting traces: NMDA receptor activation and Ca2+ concentration in dendritic spine. Bridges simplistic phenomenological rules and highly detailed models, reproducing both pairwise STDP and triplet nonlinearities in hippocampal culture and cortical slices.
Source: arXiv:1410.0557v1 (Neural Computation 2015) Utility: 0.90
Trace 1: NMDA Receptor Activation
x(t) = fraction of activated NMDA receptors
Decays with time constant τ_x
Trace 2: Ca2+ Concentration
y(t) = Ca2+ concentration in dendritic spine
Decays with time constant τ_y
Pairwise STDP:
Δw = A+ * x_pre * y_post - A- * x_post * y_pre