Neuromodulation mechanisms supporting robust rhythmic pattern transitions in central pattern generators. Activation: neuroscience, neuromodulation, cpg.
Many essential biological functions, such as breathing and locomotion, rely on the coordination of robust and adaptable rhythmic patterns, governed by specific network architectures known as connectomes. Rhythmic adaptation is often linked to slow structural modifications of the connectome through synaptic plasticity, but such mechanisms are too slow to support rapid, localized rhythmic transitions. Here, we propose a neuromodulation-based control architecture for dynamically reconfiguring rhythmic activity in networks with fixed connectivity. The key control challenge is to achieve reliable rhythm switching despite neuronal degeneracy, a form of structured variability where widely different parameter combinations produce similar functional output. Using equivariant bifurcation theory, we
Last updated: 2026-04-09