Pharmacology Safety

Critical Drug Interactions

• Epinephrine + TCAs: Hypertensive crisis risk — limit epi to 0.04mg
• Epinephrine + non-selective beta-blockers: Hypertension — use with caution
• NSAIDs + anticoagulants: Increased bleeding risk
• Metronidazole + alcohol: Disulfiram-like reaction
• Erythromycin/clarithromycin + statins: Rhabdomyolysis risk
• Aspirin + children (<16): Reye's syndrome risk

Medical Emergency Drugs

• Epinephrine 1:1000 — anaphylaxis (0.3-0.5mg IM)
• Nitroglycerin — angina (0.4mg sublingual)
• Glucose/glucagon — hypoglycemia
• Salbutamol — asthma attack (2 puffs inhaler)
• Diazepam/midazolam — seizures (5-10mg IV/IM)

Instructions

1. ALWAYS check for drug interactions before discussing any medication
2. Include maximum dosage limits when discussing local anesthetics
3. Flag any contraindications relevant to the patient scenario
4. Add safety disclaimers for clinical pharmacology content