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Trial Eligibility Agent | Skills Pool

Skill File

Trial Eligibility Agent

Parse trial protocols and patient data to produce criterion-level MET/NOT/UNKNOWN determinations with evidence and gaps for clinical trial screening tasks.

mdbabumiamssm24 starsFeb 2, 2026

Occupation
Categories: Computational Chemistry

Skill Content

At-a-Glance

description (10-20 chars): Trial triage hub
keywords: eligibility, ClinicalTrials, FHIR, evidence, gaps
measurable_outcome: Produce a MET/NOT/UNKNOWN matrix with supporting citations for ≥90% of inclusion/exclusion criteria within 5 minutes per trial request.

Inputs

trial_id (NCT or sponsor ID) plus protocol text if not public.
patient_summary narrative and optional patient_structured FHIR bundle.
Declare data sources used (notes, labs, imaging, meds) to show provenance.

Outputs

Structured table (JSON recommended) listing each criterion id/text with status, evidence snippet, and confidence.
Overall recommendation (potentially_eligible, not_eligible, needs_more_information).
Data gap checklist covering missing labs/imaging/biomarkers.

Related Skills

Quick Install

Trial Eligibility Agent

npx skillvault add mdbabumiamssm/mdbabumiamssm-llms-universal-life-science-and-clinical-skills-skills-clinical-trial-eligibility-agent-skill-md

Download Skill Open repository

Author: mdbabumiamssm
stars: 24
Updated: Feb 2, 2026
Occupation

On this page

Workflow

Acquire protocol: Pull eligibility text from ClinicalTrials.gov or sponsor PDF.
Normalize criteria: Break into atomic checks with AND/OR logic and thresholds.
Extract patient facts: Map narrative + FHIR data into canonical features (age, labs, ECOG, biomarkers).
Evaluate: Assign MET/NOT/UNKNOWN with cited evidence for each criterion, flag missing context explicitly.
Summarize: Present recommendation and highlight gating unknowns plus next-best actions.

Guardrails

Never claim enrollment decisions; mark outputs as advisory.
Cite direct patient evidence for every MET/NOT call; default to UNKNOWN rather than guessing.
Respect PHI handling expectations—avoid storing raw notes outside secure paths.

Tooling & References

Use README.md for API snippets (FHIR parsing, JSON schema) and dependency versions.
Pair with Clinical/Trial_Matching/TrialGPT when retrieval/ranking is also needed.

02

Inputs

06Tooling & References

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