Managing Peripheral Vascular Disease

Documents to Request

• ABI measurement report (resting and post-exercise if available)
• Segmental pressure and pulse volume recording (PVR) study
• Duplex ultrasound of lower extremity arteries
• CTA or MRA of aorto-iliac and lower extremity vasculature (if intervention planned)
• Wound assessment documentation (if tissue loss present)
• Current medication list
• Lipid panel, HbA1c, renal function
• Smoking history and cessation status
• Prior vascular interventions or surgical reports

Step 1: Diagnosis and Severity Classification

ABI Interpretation:

Toe-Brachial Index (TBI): Use when ABI > 1.40 (non-compressible)

• Normal: ≥ 0.70
• Abnormal: < 0.70

Exercise ABI: Perform when resting ABI is borderline (0.91–0.99) and symptoms suggest PAD

• Drop in ABI ≥ 20% post-exercise = hemodynamically significant PAD

Fontaine / Rutherford Classification:

Step 2: Medical Management (All PAD Patients)

Cardiovascular Risk Reduction (Class I for all PAD patients):

Antiplatelet Intensification:

• COMPASS trial: rivaroxaban 2.5 mg BID + aspirin 100 mg daily — superior to aspirin alone for PAD patients (28% reduction in MALE, 24% reduction in MACE)
• Consider COMPASS regimen for stable PAD without high bleeding risk

Claudication-Specific Therapies:

• Cilostazol 100 mg BID: phosphodiesterase-3 inhibitor; increases walking distance 40–60% (contraindicated in HF)
• Supervised exercise therapy: > structured walking program (30–45 min, 3×/week, minimum 12 weeks) — Class I, comparable benefit to revascularization for claudication

Step 3: Non-Invasive Vascular Testing

Segmental Pressures and Pulse Volume Recordings (PVR):

• Pressure gradient > 20 mmHg between adjacent segments = hemodynamically significant stenosis
• PVR waveform analysis: normal (sharp systolic peak, dicrotic notch) → progressive blunting indicates proximal disease

Duplex Ultrasound:

• Peak systolic velocity (PSV) ratio ≥ 2.0 at a stenosis = ≥ 50% stenosis
• PSV ratio ≥ 4.0 = ≥ 75% stenosis
• Absent flow = occlusion

CTA/MRA (Pre-Intervention Planning):

• CTA: preferred for calcified vessels, post-stent surveillance
• MRA: preferred when avoiding contrast (renal insufficiency) or iodine allergy; may overestimate stenosis
• Document: inflow (aorto-iliac), outflow (femoropopliteal, tibial), and runoff vessels

Step 4: Revascularization Decision-Making

Indications for Revascularization:

• Lifestyle-limiting claudication refractory to ≥ 3 months supervised exercise + pharmacotherapy
• Critical limb-threatening ischemia (rest pain, tissue loss)
• Acute limb ischemia (emergent)

CLTI WIfI Classification (Wound, Ischemia, Foot Infection):

• Wound grade (0–3): based on ulcer depth and gangrene extent
• Ischemia grade (0–3): based on ABI, ankle pressure, TP
• Foot infection grade (0–3): based on IDSA/IWGDF criteria
• WIfI stage predicts amputation risk and revascularization benefit

Revascularization Approach:

• Aorto-iliac disease: endovascular first (stenting) for focal lesions; surgical bypass (aortobifemoral) for extensive disease (TASC D)
• Femoropopliteal disease: endovascular for short lesions (< 25 cm); bypass for long occlusions with good conduit (autogenous vein preferred)
• Infrapopliteal disease: endovascular preferred for CLTI; balloon angioplasty ± drug-coated balloon

Acute Limb Ischemia (6 P's): Pain, Pallor, Pulselessness, Paresthesias, Paralysis, Poikilothermia

• Rutherford acute classification I–III determines urgency (viable → irreversible)
• Class I–IIa: anticoagulate with heparin; plan revascularization
• Class IIb: emergent revascularization (thrombectomy, thrombolysis, or bypass)
• Class III: irreversible; consider primary amputation

Step 5: Surveillance and Long-Term Management

Post-Revascularization Surveillance:

Long-Term Monitoring:

• ABI measurement annually (or with symptom change)
• Cardiovascular risk factor reassessment at each visit
• Wound healing assessment for CLTI patients (weekly until healed)
• Foot care education and podiatric referral for diabetic patients

Checkpoint B: Post-Draft Alignment (Mandatory)

1. Is the ABI documented and correctly interpreted?
2. Is the severity classified by Fontaine/Rutherford?
3. Are all cardiovascular risk reduction therapies addressed?
4. Is supervised exercise therapy prescribed for claudication patients?
5. Is the revascularization decision supported by objective hemodynamic and anatomic data?

Quality Audit

• ABI measured and interpreted (or TBI if non-compressible)
• Exercise ABI performed for borderline resting ABI
• PAD severity classified (Fontaine/Rutherford)
• Pulse examination documented (femoral through pedal)
• Antiplatelet therapy initiated or documented
• High-intensity statin prescribed
• Smoking cessation addressed with pharmacotherapy options
• BP target < 130/80 with ACEi/ARB preferred
• Supervised exercise therapy prescribed for claudication
• Cilostazol considered (no HF contraindication)
• COMPASS regimen (low-dose rivaroxaban + aspirin) considered
• Non-invasive imaging appropriate for clinical stage
• CLTI assessed with WIfI classification if tissue loss present
• Revascularization indication and approach documented
• Surveillance protocol assigned post-intervention

Guidelines

1. Screen for PAD with ABI in patients ≥ 65, or ≥ 50 with diabetes or smoking history — PAD is underdiagnosed because many patients are asymptomatic.
2. A non-compressible ABI (> 1.40) does NOT rule out PAD — use toe-brachial index, which is unaffected by medial calcification.
3. Supervised exercise therapy is a Class I recommendation for claudication and should be offered before revascularization — studies show comparable improvement in walking distance.
4. Cilostazol is the only FDA-approved medication for claudication symptom relief — do not use in patients with any degree of heart failure.
5. The COMPASS trial regimen (rivaroxaban 2.5 mg BID + aspirin) should be considered for all stable PAD patients to reduce major adverse limb and cardiovascular events.
6. For CLTI, multidisciplinary limb salvage teams (vascular surgery, podiatry, wound care, endovascular) improve outcomes — avoid uncoordinated referrals.
7. Smoking cessation is the single most impactful intervention for PAD progression — document cessation counseling and pharmacotherapy at every encounter.
8. Post-revascularization duplex surveillance is essential — early detection of restenosis allows reintervention before graft/stent failure and limb loss.