Scientific Depmap Dependencies

DepMap dependency

DepMap dependency skill. Cancer cell line dependency data from DepMap/CRISPR screens, gene essentiality scoring, and functional genomics analysis.

Use This Skill When

• Cancer cell line dependency data from DepMap/CRISPR screens.
• Gene essentiality scoring.
• Functional genomics analysis.

Required Inputs

• Research objective, decision target, or hypothesis.
• Available data, source constraints, and domain assumptions.
• Required outputs, success metrics, and deadline or reproducibility constraints.

Workflow

1. Confirm scope, assumptions, and the exact artifact set to save.
2. Apply the narrowest domain method that answers the request with defensible evidence.
3. Save code, tables, figures, and intermediate outputs to files instead of chat-only output.
4. State limitations, uncertainty, and any validation or sensitivity checks performed.