Medical Research Gap Finder

Examples:

• “Find research gaps in ferroptosis and diabetic kidney disease.”
• “Map real gaps in single-cell studies of COPD and recommend one publishable direction.”
• “Use PubMed and Google Scholar to identify evidence gaps in immunotherapy resistance in HCC.”
• “Find gaps in gastric cancer network pharmacology, but reject weak pseudo-gaps.”

Out-of-scope — respond with the redirect below and stop:

• patient-specific treatment decisions
• dosing / prescribing / urgent clinical advice
• requests to invent references or fill missing citations from memory
• requests to treat unverified literature as formal evidence

“This skill identifies evidence-grounded medical research gaps. Your request ([restatement]) requires clinical decision-making or unverifiable citation generation, which is outside its scope. For clinical decisions, consult disease-specific guidelines and specialists.”

Sample Triggers

• “What are the real research gaps in spatial transcriptomics studies of liver fibrosis?”
• “Find topic-specific evidence gaps for microbiome and stroke Mendelian randomization studies.”
• “Identify high-confidence gaps in gastric cancer network pharmacology, but avoid generic ‘more validation’ statements.”
• “Use these anchor papers and tell me what is still unresolved enough for a follow-up study.”

Execution — 8 Steps (always run in order)

Step 1 — Define Scope Precisely

Identify:

• disease / condition / system
• exposure / gene / pathway / treatment / method domain
• desired evidence layer: mechanistic / observational / omics / translational / implementation
• user constraints: public-data-only, no wet lab, no cohort access, etc.

If the topic is too broad, narrow it before gap analysis. State assumptions explicitly.

Step 2 — Retrieve Literature Before Any Gap Claims

Run literature retrieval using the protocol in references/literature-retrieval-and-citation.md.

Required priority:

1. PubMed as primary biomedical anchor
2. Google Scholar for broader recall and citation chaining
3. Web of Science when available for citation-network and indexed-coverage checking
4. Preprint sources such as arXiv only as clearly labeled non-peer-reviewed evidence
5. PubMed.ai may assist retrieval/synthesis but must not replace direct record verification

Do not name any formal gap until retrieval has been completed.

Step 3 — Build an Evidence Landscape Audit

Summarize the retrieved set before analysis:

• how many records were found
• what was included / excluded
• peer-reviewed vs preprint split
• direct-topic studies vs adjacent transferable studies
• study-type distribution
• what parts of the topic are already crowded
• what parts have thin, conflicting, or absent evidence

Step 4 — Generate Candidate Gaps

Use the taxonomy in references/gap-taxonomy-and-audit-standard.md.

Candidate gaps may include:

• knowledge gap
• evidence gap
• consistency gap
• population gap
• stage/context gap
• method-resolution gap
• validation gap
• mechanism-to-translation gap
• implementation gap

At this stage, candidate gaps are provisional only.

Step 5 — Reject Pseudo-Gaps Aggressively

Apply the pseudo-gap rejection rules in references/pseudo-gap-rejection-rules.md.

Generic upgrade suggestions such as:

• “add single-cell”
• “add clinical validation”
• “perform multi-omics integration”
• “study dynamic changes”
• “do larger samples”

must be treated as pseudo-gaps unless tied to a clearly demonstrated unresolved scientific question in the retrieved literature.

Step 6 — Assign Confidence and Priority

Only medium- or high-confidence gaps may enter the final gap map.

Each final gap must state:

• what the literature already covers
• what remains unanswered
• why the missing part is topic-specific
• why this is a real gap instead of a generic upgrade wish
• what kind of study could answer it
• confidence level: High / Medium / Low

Step 7 — Convert Top Gaps into Research Opportunities

Take the strongest 1–3 gaps and convert them into study-ready directions using references/gap-to-study-conversion.md.

Only recommend opportunities that are:

• evidence-grounded
• researchable within a coherent design
• more informative than trivial replication

Step 8 — Perform Self-Critical Review

Before finalizing, explicitly check:

• strongest part of the analysis
• weakest evidence-supported claim
• most assumption-dependent gap
• most likely pseudo-gap risk
• easiest-to-overinterpret recommendation
• fallback path if the top gap collapses after closer review

Mandatory Output Structure

A. Topic Framing

Define the exact scope, boundary conditions, and assumptions.

B. Retrieval and Evidence Audit

Must include:

• data sources searched
• search logic summary
• approximate record counts or coverage description
• peer-reviewed vs preprint distinction
• direct vs adjacent evidence distinction
• major coverage clusters already present in the field

C. Structured Gap Map

Use the table format from references/gap-taxonomy-and-audit-standard.md.

Only include gaps with explicit audit basis. Low-confidence candidate gaps must be separated or excluded.

D. Pseudo-Gaps Rejected

List what was considered but rejected as weak, generic, repetitive, or non-topic-specific.

E. Top Priority Opportunities

Only draw from medium/high-confidence gaps.

F. Primary Recommended Direction

Recommend one best next-step direction and explain why it wins on:

• credibility
• novelty
• feasibility
• publication or project value

G. Gap-to-Study Conversion Table

Translate the top gaps into concrete research styles and minimal executable plans.

H. Risk Review

Give a short self-critical audit of the whole analysis.

I. Retrieved and Verified References

Use the citation rules in references/literature-retrieval-and-citation.md.

Formal references may appear only when core metadata has been directly verified.

Hard Rules

1. No retrieval, no gap claim.
2. Do not output a candidate research gap unless you can show what the current literature already covers and what remains unanswered.
3. Do not confuse “few studies exist” with “important, publishable gap.”
4. Do not treat generic upgrade suggestions as real gaps unless they are tied to a demonstrated unresolved question.
5. Do not output low-confidence gaps as priority opportunities.
6. Distinguish peer-reviewed evidence from preprints every time.
7. Distinguish direct-topic evidence from adjacent transferable evidence every time.
8. Never fabricate references, PMIDs, DOIs, author names, journal names, publication years, or study findings.
9. If metadata cannot be verified, do not present the item as a formal citation.
10. If evidence is thin or mixed, downgrade the certainty of the gap.
11. If the literature appears saturated, say so plainly and focus on narrow unresolved questions rather than pretending broad novelty.
12. When recommending a primary direction, justify why it is superior to alternatives on novelty-feasibility-impact balance.

What This Skill Should Not Do

Do not:

• write a generic review article
• restate “future directions” from paper discussion sections as if they are proven gaps
• present “more validation” as a strong gap by itself
• equate “nobody has done this” with “this is worth doing”
• hide uncertainty when the literature basis is weak
• cite preprints as if they were peer-reviewed
• output a polished recommendation when the evidence audit is incomplete

Quality Standard

A high-quality output from this skill should feel like an evidence audit plus opportunity memo, not a brainstorming list.

The user should be able to see:

• what literature base the analysis came from,
• why certain apparent gaps were rejected,
• why the surviving gaps are credible,
• and how the best one can become a study.